Journal article
Host genomics and HCV treatment response
PJ Clark, AJ Thompson
Journal of Gastroenterology and Hepatology Australia | WILEY | Published : 2012
Abstract
In 2009, an association between the interleukin-28B (IL28B) polymorphism and treatment outcome for genotype 1 (G1) hepatitis C virus (HCV) infection, as well as spontaneous clearance of HCV, was reported. Since the initial publications, over 100 articles have appeared in the peer-reviewed literature, with many more manuscripts in press and abstracts presented at scientific meetings. Despite the proliferation of data concerning the IL28B polymorphism and HCV infection, there remain many critical unanswered questions about clinical implications and the underlying biological mechanisms. In this review, we discuss the basic principles of genome-wide association study methodologies that are impor..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
AJT has received research support from Merck, Roche, and Gilead Sciences; has served as a consultant for Merck, Roche and Janssen-Cilag; and has served on a speaker bureau for Merck. PJC has received funding support from the Duke Clinical Research Institute, the Richard Boebel Family Fund, the National Health and Medical Research Council of Australia (APP1017139), and the Gastroenterological Society of Australia. AJT has received funding from the National Health and Medical Research Council of Australia (APP567057). PJC has received funding from the National Centre in HIV Epidemiology and Clinical Research (now The Kirby Institute for Infection and Immunity in Society), University of New South Wales, and the AASLD/LIFER Clinical and Translational Research Fellowship in Liver Diseases Award.